A PROTOCOL FOR PERMISSIVE WEIGHT-BEARING DURING ALLIED HEALTH THERAPY IN SURGICALLY TREATED FRACTURES OF THE PELVIS AND LOWER EXTREMITIES

A protocol for permissive weight-bearing during allied health therapy in surgically treated fractures of the pelvis and lower extremities

Objective: To optimize rapid clinical recovery and restoration of function and functionality, permissive weight-bearing has been designed as a new aftercare mobilization regimen, within the upper boundary of the therapeutic bandwidth, yet safe enough to avoid overloading.The aim of the present paper is to describe a comprehensive protocol for permi

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Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans.Using single-cell transcriptomic and mouse genetic approaches, we show that michael harris ii headband proximal tubular (PT) cells develop a molecularly dist

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